CONCLUSION
·
The word Chitraka is not found in Vedic periods
but since Samhita Period it has been used in medicine. Ayurvedic Classics have
described wide range of therapeutic properties of the plant and have indicated
in Medoroga, Arsha, Grahani,
Udara, Shoola, Kushta, Meha, Shwitra, Gulma etc.
·
Chitraka has Katu, Tikta rasa; Katu vipaka;
Laghu, Ruksha, Ushna Guna; and Ushna Veerya.
·
Botanical source of Chitraka is Roots of Plumbago zeylanica Linn. The root and root bark of Plumbago species contains Plumbagin,
which is therapeutically an important alkaloiod.
·
In Ayurveda, there is no direct reference of a
single disease entity that can be directly correlated with the hyperlipidaemia.
Most of the scholars have considered hyperlipidaemia under the heading of Medoroga.
·
Medoroga is the produced as a result of
medodhatvagnimandya and it is Vatakapha pradhana vyadhi.
·
The phytochemical studies have revealed that the
trial drug Chitraka is rich source of alkaloids, flavonoids, glycoside and
tannin.
·
Safe dose of alcohol extract is
considered to be 200mg/kg body weight in albino rats. Dose of the Chitraka
churna is decided by referring the table of Paget and Barnes (1964) as 180mg/kg
body weight.
·
The trial drug is found to be free from any sort
of side effects or toxic effects during the experimental study.
·
Alcohol extract of Chitraka showed more
significant hypolipdaemic effect, when compared to Chitraka churna.
·
It was also effective in reducing hyperglycemia,
which was also induced by hydrocortisone.
·
It also reduced tissue lipid content of liver
and regressed atheroma and plaque formation in aorta.
·
Chitraka with its deepana & pachana action
encounters dhatvagnimandya & potentiates the dhatvagni. That in turn helps
to form the dhatus in proper proportion with samyak qualities. Their by it
ensues sarvadhatuposhana.
·
Chitraka is an effective hypolipidaemic drug
which is established through this experimental study using glucocorticoid
induced hyperlipidaemic experimental model.
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