AMLAPITTA

 

Introduction:

Amlapitta is a disease appears in Annavahu srotas particularly in amashaya or stomach. Its classical symptom are pain abdomen & sour bleaching stated by Acharyas. The word Amlatwa indicates the amlatwa of pitta, because the pitta instead of attaining its natural katupaka like smoking, chewing tobacco, consuming alcohol which has become symbol of modernization or disease, may be an outcome of stress & strain which have become unavoidable in the daily life. It is (Amlapitta) developed with these factors causing amlatwa (sourness) in the food ingested or even with the factors responsible for vitiation of pitta.

Acharya Kashyapa has explained the etiological factors of amplapitta as diminished kayagni or Jathragni which is consider as pitta according to Sushruta. All the provinces of world will have their own food habit leads to the various disorders. Not only food but also janapadadwamsa karnnas like vayu & jala also responsible factors for alternation for gastric rhythm & causation of amashaya samutha vyadhi like amlapitta. It is going to be develop because of excess secretion of HCL acid in the stomach as reflex action or long time stasis of food in the stomach because of diminished activity of peristalsis.

It can be co-related with hyperacidity associated with peptic ulcer in modern science. Alteration in thickness of gastric muscularis mucosa by imbalance between the aggressive secretion of acid & defensive factors leads to gastric ulceration. It is well known that the gastric mucosa can resist auto-digestion through it in exposed to numerous noxious stimuli like aggressive secretion of HCL, pepsin, reflex of bile, spicy food, microorganisms, formation of free radicals, stress, alcohol & irritant drugs & consuming NSAID’s like ibuprofen, diclofen, rofecoxib etc are important aetiological factors for 30% of gastric ulcer formation. It is thus evident that the integrity of gastric mucosa is maintained by defensive mechanism against these aggressive damaging factors.

The prevalence of ulcer is decreasing in many western communities; it still affects approximately 10% of all adults. The male to female ratio for ulcer varies from 5:1 to 2:1. The highest prevalence of peptic ulcer in India is in Kerala & Tamilnadu. In India duodenal ulcer are for more common than gastric ulcer (8:1 to 20:1).

This ulcer if no treated in time & properly, many leads to harmfulness, malaria, perforation of duodenal ulcer are not uncommon now a days which gives 50% of survival chances.

To avoid such hazards, in the commercial word a number of medicines are available. But Rasoushadhis have few advantages like alpamntra, Aruchi heenata & Sheegratabha. In asadhya rogas also rasaoushadhis are indicated. Among these Leelavilasa rasa is beneficial for the Amlapitta which contains the maximum minerals which are helpful for quick relief & also acts as a Rasayana.

 

 

Material & methods

Intgradients of Leela vilasa rasa :

S. Parada                                -           2 Phala

S. Gandhaka                           -           2 Phala

Abhraka Bhasma                   -           2 Phala

Tamra Bhasma                      -           2 Phala

Loha Bhasma                         -           2 Phala

Amalaki swarasa

Bhibitaki swarasa                             Bhavanartha

Bhringaraja swarasa

 

The whole procedure can be divided in to 3 headings.

1)     Poora Karma

2)     Pradhana Karma

3)     Paschat Karma

 

1)Poorva Karma:    a) Collection of appropriate equipments

                                    b) Collection of drugs

                                    c) Shodhna & Marana of the drugs (Minerals)

                                    d) Preparation of kajjali

2) Pradhana Karma

                                    Preparation of the Vati

a)     Mixing of the bhasmas into the kajjali

b)     Bhavana process – 3-3 bhavana of each drug

c)      Preparation of the

3) Paschat Karma

                                    a) Storage of the vati

                                    b) Storage of the vati

                                    c) Matra : 1 Ratti

                                    d) Anupana : Madhu

 

Pharmaco kinetic of individual drugs

 

Sr. No.	Dravya	Absorption	Distribution	Exertion
1	Parada	GIT	Bloodcells, Liver, Kidney, Brain	Kidney, Large bowel
2	Gandhaka	Intestine	Distributed in the form of organic compounds hyparin, cystain, keratins	Stool & Urine
3	Abhraka	GIT	GIT & Respiratory system	Stool
4	Tamra	GIT	All over the body	Stool & Urine
5	Loha	GIT	All over the body	Stool & Urine
6	Amalaki	GIT	All over the body	Stool & Urine
7	Bibhitaki	GIT	All over the body	Stool & Urine
8	Bhringaraja	GIT	All over the body	Stool & Urine

 

DISCUSSION

1)Parada

Rasa: Shadrasa                                             Guna: Snigdha, Sara

Veerya: Ushna                                              Vipaka: Madhura

Doshaghnata: Tridosha Shamaka             Karma: Rasayana, Sarvaroghara

Mercury readily forms co-velent bond with sulphur & this property that accounts for most of the biological properties of the metal. Organic mercurial forms the bond R-Hg-SR where R-protein.

Action: Protien has a specific function in the micro-organism. Eg-enzyme, the formation of disulphide bond will alter conformation (shape) of the protein & alter its function. The overall change or distruction of the micro-organism.

 

 

 

2) Gandhaka

Rasa: Katu, Tikta, Kashaya                                      Guna: Ushna, Sara

Veerya: Ushna                                                          Vipaka: Madhura (RC), Katu (AP)

Doshaghnata: Kapha Vata Shamaka                     Karma: Depana, Pachana, Rasayana

 

Ø  Sulpher is one of the nutritionally essential element it forms many protein in the body. It also act as antimicrobial & Bacteriostatic.

Ø  Gandhaka shows detoxication action, controls oxidation maintain the smooth & hardness of the tissue & enhances the tissue metabolic rate & respiration.

Ø  Main content of essential amino acid which are nourishes the body

Ø  Agnideepaka & Amapachana : Bile juice is essential to digest the food. Bile juice contains inurochloric acid which is delivered from the tourine. This tourine is synthesized by Sulpher containing aminoacid.

Ø  A high energy sulphur bond similar to that of phosphate plays an important role in metabolism.

Ø  Inorganic sulphate neutralizing alkalies & this helps to maintain blood reaction constant.

 

3) Abhraka

Rasa: Madhura                                             Guna: Snigdha

Veerya: Sheeta                                             Vipaka: Madhura

Doshaghnata: Kapha, Vata Shamaka        Karma: Deepaka, Pachaka, Ruchivardhaka

                                                                                       Amlapittanashaka

 

Ø  It is disinfected to some extent. In gastric mucosa it forms the silica acid & aluminium chloride. It has astringent property. The later acting as protective to the gastric mucosa.

Ø  Abhraka bhasma has the anti histamine property, it inhabits the further stimulation of the partial cells to release of HCL acid.

Ø  Abhraka bhasma possesses high antacid property & was found highly effective in preventing the histamine induced ulcers of stomach tissues in experimental guinpigs. In clinical cases also it was found very effective in curing the hyperacidity condition & in relieving the symptoms of amlapitta within 10 days treatment.

 

 

 

 

 

 

4)    Tamra

Rasa: Lavana vargita panchrasa                Guna: Laghu, Sara

Veerya: Sheeta(su), Ushna (RC)                 Vipaka: Madhura (RC) Katu (AP)

Doshaghnata: Kaphapitta Shamaka                      Karma: Ropana, Deepana, Amlapittahara

 

Ø  Astrigent, Sedative, Antispasmodic, Alternative, Antiseptic. In small doses it is astringent. In large doses it is alternative due to this action it costs on the surface of the mucous membrane. It protects the mucous membrane from acid.

Ø  Tamrabhasma may increase gastric muscosal resistance to damage. By

a) Increased muscosal sialmucin & fucose contents

b) Decreased gastric juice &DNA

c) No change in DNA & the incorporation of (SH) – thyxidine into mucosal cell DNA   

Ø  Tamm bhasma increases the prostaglandins at a rate of 38%. It shows mucosal protectivity activity.

Ø  Cuprous oxide absorption in gastrum is very low. Maximum absorption is in colon. So it is useful in Adhoga amlapitta or inflammatory bowl diseases as same effect.

Ø  A minimum oral dose of 1mg/ kg. wt of tamra bhasma shows anti ulcergenic activity by decreasing the total acid pepsin out put & an increasing the carbohydrate/ protein ratio which indicates increased mucous secretion in the gastrium.

Ø  Copper even act as a anti inflammatory activity.

 

4) LOHA

Rasa : Tikta, Kashaya                                   Gunna : Laghu, Sara

Veerya : Sheeta (Su), Ushna (RC)               Vipaka : Madhura

Doshaghnata : Kaphapittashamaka          karma : Koshtashodhana, Amahara, Rasayana.

Ø  It is also good astringent due to this it coats on the surface of the mucous membrane & protects it form the acid.

Ø  It shows good ulcer healing activity.

 

5) AMALAKI

Rasa : Lavanavarjita pancharasa               Gunu : Guru, Roksha, Sheeta

Veerya : Sheeta                                            Vipaka : Madhura

Doshaghnata : Tridosha shamaka                        Karma : Deepana, Rasayana, Dahapashamana
                                Amalatanashaka

Chemical composition Tannins, Fractose, Galactose etc. Action : Astrigent, Purgative, Dueto presence of fructose, Galactose etc neutralizes the gastric acid it is good hepatorprotective drug.

It shows good ulcer healing activity.

6) BIBHITAKI :

Rasa : Kashaya         Madhura                    Guna : Rooksha, Laghu

Veerya : Sheeta                                            Vipaka : Madhura

Dushghnata : Kaphapitta shamaka           karma : Deepana, Chardi nigraha

Chemical comp; Tannins, fructose, galactose, glucorhomnose galic acid etc

Action: Astrigent, purgative, due to presence of fructose, galactose etc neutralizes the gastric secretion & it is good hepatoprotective drug.

 

8) BHRINGARAJA :

Rasa : Katu, Tikta                                         Guna : Rooksha, Laghu

Veerya : Ushna                                             Vipaka : katu

Doshaghnata : Kaphavata shamaka          Karma : Deepana, Pachana,

                                                                                                Ekrut Uttejaka

Chemical gropu : Ecliptine, Weedololactone

Action : It is best live stimulant it regulates the bile secretion by that it controls the release of HCL acid.

 

7) MADHU :

Rasa : Kashaya, Madhura                            Guna : Guru, Rooksha

Veerya : Sheeta                                            Vipaka : Katu

Doshaghnata : kaphapitta shamaka          karma : Vrunaropaka

Chemical comp : it is mixture of dextrose & levelose monosaceharides. Rich in carbohydrates, calcium phosphate & iron phosphate.

Action : It has demulcent property, It elevates the irritation of the mucous membrane. It coats the mucous membrane & reduces the friction & irritation.

Introducing on said causation factors

 

Pitta dosha prakopa

 

Agnimandya

 

Pittolbana

(By amla, Vidahi etc)

 

Amlabhavata of pitta

 

Amshayashritam                                      Turns sukta                                            Ama

                                                                                                                    (Yields toxic substance)

 

   Amlapitta                                                Combines pitta

 

 

 

 

 

 

 

 

 

 

 

MODE OE ACTIONS :

PITTA PRAKOPA                               PARADA, LOHA, TAMRA, AMALAKI & BIBHTAKI

 

AGNIMANDYA                                   GANDHAKA, BHRINGARAJA, TAMRA

 

AMLATWA OF PITTA                       TAMRA, AMALAKI, ABHRAKA

 

MUSCULAR LAYER                            TAMRA, AMALAKI, ABHRAKA

REGISTANCE

 

COMPLICATIONS                               LOHA, ABHRAKA, TAMRA

(Shoola jwara etc)

 

 

 

 

 

 

 

 

 

 

 

 

 

 

CONCLUSION :

v  Amlapitta is acommon disease maximumly available in the present da due to the change in life style. The prevalence rate from mile to female is 5:1 to 2:1

v  This combination gives a good results as each ingredient shows the specific action

 

i.e

§  Para, Gandhaka         -           Agnideepaka, Pittashamaka, Antimicrobial activity &
                                                best rejuvinity

§  Tamra                         -           Tridosha shamaka, Antacid, Antiulcer activity. Mucosal
                                                protectivity activity, Antiinflammatory & muscular
                                                resistant activity.

§  Abhraka                     -           Antacid, Mucosal protective, Rasayana (Due to
                                                astringent activity)

§  Loha                           -           Ulcer healing activity. Vedhana shamaka & Rasayana

§  Amalaki & Bibhitaki  -           Antacid, Ulcer healing activity

§  Bhringaraja                -           Hepatoprotectivity, Regulates the bile secretion &
                                                controls the bile secretion

§  Madhu                                    -           Mucosal protectivity activity.

 

v  The quotation Alpamatra ---- Fullfiled by the rasaushadhies i.e tamra bhasma at a very maximum dose of 1mg/kg wt shows best anti ulcer

 

REFERENCES :-

·         Bhaishajya ratnavali

·         Rasamrita

·         Ayurvediya rasashastra

·         Dravya guna vignana

·         Pharmacology

·         Matris medica